This tab has 2 functions:
The top setting controls the start up mode of the analysis software. If the option is unticked then when you start analysis you are given the option of the start up mode. If this box is ticked then you can skip this option and force the software to start in a particular mode.
The other settings control how variables are activated and which variables are calculated when a run is loaded. For more information about these options please check this link: Variable calculation
The final option controls the Autosave, which causes the software to automatically save everything at the specified interval. In the case of the software unexpectedly shutting down, then next time the software is restarted the user will be given the option of loading this backup file.